Chemically triggered release of 5-aminolevulinic acid from liposomes
نویسندگان
چکیده
منابع مشابه
Chemically triggered release of 5-aminolevulinic acid from liposomes.
5-Aminolevulinic acid (5-ALA), a prodrug of Protoporphyrin IX (PpIX), is used for photodynamic therapy of several medical conditions, and as an adjunct for fluorescence guided surgery. The clinical problem of patient photosensitivity after systemic administration could likely be ameliorated if the 5-ALA was delivered more selectivity to the treatment site. Liposomal formulations are inherently ...
متن کاملSelective non-covalent triggered release from liposomes.
A zinc(II)-dipicolylamine coordination complex selectively associates with anionic liposomes, including sterically protected PEGylated liposomes, and causes rapid leakage of encapsulated contents.
متن کاملMechanical release from paramagnetic liposomes triggered by low frequency ultrasound
Introduction Non, or minimally, invasive in vivo visualization of drug release triggered by externally-applied physical stimuli, like heating, light or ultrasound (US) is an emerging topic in molecular medicine. As far as US is concerned, most of the published investigations were performed using nanoor micro-bubbles in which the presence of the gas-filled core makes cavitation (and US detection...
متن کاملpH-Triggered Echogenicity and Contents Release from Liposomes
Liposomes are representative lipid nanoparticles widely used for delivering anticancer drugs, DNA fragments, or siRNA to cancer cells. Upon targeting, various internal and external triggers have been used to increase the rate for contents release from the liposomes. Among the internal triggers, decreased pH within the cellular lysosomes has been successfully used to enhance the rate for releasi...
متن کاملThermosensitive liposomes modified with poly(N-isopropylacrylamide-co-propylacrylic acid) copolymers for triggered release of doxorubicin.
A novel polymer-modified thermosensitive liposome (pTSL) was developed for the delivery of Doxorubicin (DOX) for cancer therapy. Copolymers containing temperature-responsive N-isopropylacrylamide (NIPAAm) and pH-responsive propylacrylic acid (PAA) were synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization, yielding copolymers with dual pH/temperature-dependent p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: RSC Adv.
سال: 2014
ISSN: 2046-2069
DOI: 10.1039/c4ra10340h